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An eight-year-old boy from Guatemala died shortly after midnight on Christmas Day after being apprehended over an illegal entry attempt within the past month.
In a statement, US Customs and Border Protection said the eight year old had displayed "signs of potential illness" on Monday and was taken to a hospital in Alamogordo, New Mexico, where the boy was diagnosed with a cold and a fever. He was released with medical prescriptions yet returned to the hospital on Monday evening after he began vomiting, where he died just hours later, the statement added.

The agency said that the cause of death had not been determined, and that the Department of Homeland Security's inspector-general and the Guatemalan government had been notified.

On December 8, a seven year-old Guatemalan girl died two days after she was apprehended together with her father for illegal entry into the United States as part of a group of 163 undocumented immigrants. According to human rights activists, the girl died from septic shock, fever and dehydration. The US authorities said that the girl did not consume any food or water for several days. Homeland Security Secretary Kirstjen Nielsen said Jakelin's death was "a very sad example of the dangers of this journey."


Central American migrants, part of a caravan hoping to reach the U.S. gets settled in a shelter at the Jesus Martinez stadium, in Mexico City, Monday, Nov. 5, 2018. Thousands of Central American migrants have arrived at the stadium, still hundreds of miles away from their goal of reaching the U.S. a day before midterm elections in which they unwittingly became a central issue.

In January 2017, Trump signed an executive order that initiated the process of building a wall along the US-Mexico border. The Trump administration has requested $5 billion for the project from the Department of Homeland Security’s (DHS) budget, which Democrats and some Republicans oppose. The president believes that the wall will stop illegal migration as well as human and drug trafficking. However, after facing opposition to his initiative, Trump has declared that the federal government would be in a state of partial shutdown until he and the Democrats are able to reach a deal on border security issues.


Wednesday, 26 December 2018 00:28

Medical Marijuana is approved in Thailand

Thailand Approves Medical Marijuana in New Year's 'Gift'

Thailand approved marijuana for medical use and research on Tuesday, the first legalization of the drug in a region with some of the world's strictest drug laws.

The junta-appointed parliament in Thailand, a country which until the 1930s had a tradition of using marijuana to relieve pain and fatigue, voted to amend the Narcotic Act of 1979 in an extra parliamentary session handling a rush of bills before the New Year's holidays.
"This is a New Year's gift from the National Legislative Assembly to the government and the Thai people," said Somchai Sawangkarn, chairman of the drafting committee, in a televised parliamentary session.

While countries from Colombia to Canada have legalized marijuana for medical or even recreational use, the drug remains illegal and taboo across much of Southeast Asia, which has some of the world's harshest punishments for drug law violations.

Marijuana traffickers can be subject to the death penalty in Singapore, Indonesia and Malaysia.
But in Thailand, the main controversy with legalization involved patent requests by foreign firms that could allow them to dominate the market, making it harder for Thai patients to access medicines and for Thai researchers to access marijuana extracts.

"We're going to demand that the government revoke all these requests before the law takes effect," said Panthep Puapongpan, Dean of the Rangsit Institute of Integrative Medicine and Anti-Aging.

source/ agency newsmax


Hollywood-Los Angles

Kevin Spacey is facing a felony charge of sexual assault for allegedly assaulting a former Boston TV news anchor's teenage son in 2016.

According to the clerk's office, Spacey will be arraigned on a charge of indecent assault and battery on a person aged 14 or over at Nantucket District Court on January 7.

Globe, Cape and Islands, Massachusetts, District Attorney Michael O'Keefe told the Boston Globe that a hearing was held on December 20, where Clerk Magistrate Ryan Kearney issued a criminal complaint for the charge "against Kevin S. Fowler, also known as Kevin Spacey".


Longtime Boston journalist Heather Unruh accused Spacey last year of sexually assaulting her son at a Nantucket bar in July 2016.

The former news anchor for ABC affiliate WCVB claimed Spacey provided her 18-year-old son with numerous drinks before reaching down his pants and grabbing his genitals. Her son had told Spacey he was 21, Unruh said.

As news of the looming charges emerged, Spacey then raised eyebrows with his bizarre return to social media for the first time since 2017.

On Twitter and Instagram, the Usual Suspects actor shared a link to a YouTube video featuring Spacey delivering a three-minute monologue in character as his former House of Cards protagonist, Frank Underwood.

Except Frank Underwood was killed off between Seasons 5 and 6 of the hit Netflix series after Spacey was unceremoniously dismissed after numerous accusations of sexual misconduct came to light.

In Monday's video, titled "Let Me Be Frank," Spacey spoke directly into the camera, as was Underwood's wont, and bemoaned his current state of affairs.

But the line between Spacey and the character remained fuzzy, as he eviscerated those who wished to see him confess and lambasted others who rushed to judgment without facts.

"We're not afraid, not of what we said, not of what we did and we're still not afraid," Spacey said, ostensibly as Underwood. "Because I promise you this: If I didn't pay the price for the things that we both know I did do, I'm certainly not going to pay the price for the things I didn't do."

In the video Spacey appears to address the decision to kill off his character on the show following his firing last year. He also appears to reference the real-life allegations of sexual assault that surfaced last year, derailing his career. The video depicts Spacey in a kitchen setting wearing an apron bedecked with Santa Claus imagery.


"Despite all the poppycock, the animosity, the headlines, the impeachment without a trial. Despite even my own death, I feel surprisingly good and my confidence grows each day that soon enough you will know the full truth," Spacey says.

It could not immediately be confirmed if Spacey was in fact behind the video. Netflix declined to comment. A source close to Netflix said the streaming giant had no involvement with the video.

Reuters, Los Angeles Times

(ANSA) - Faenza (Ravenna)

The International ceramics museum in Faenza, near Ravenna, will  host two big exhibitions next year 2019, on Miquel Barcelò in the spring and Pablo Picasso in November.
    The first exhibit will be for the Spanish artist Barcelò's ceramic production ,it will be inaugurated at the end of May.
    While The other exhibit, whose exact date has yet to be released, is a unique project conceived for the museum in Faenza, where the artist's work will be displayed alongside the permanent collection, in particular local art, organizers said.
    The show 'Picasso. La sfida della ceramica' (Picasso. The challenge of ceramics) will open on November 1 next year.
    The 60 pieces to be showcased will be loaned by the Musée Picasso in Paris.
It is said that the exhibit is part of the project 'Picasso Mediterranée', which over the past two years has contributed to the organization of over 40 events across Europe, involving 100 institutions.
    The permanent collection of Faenza's ceramics museum already includes artwork donated by Picasso to help it rebuild its contemporary collection after artwork was destroyed during World War II.

Monday, 24 December 2018 21:11

Why old age lost their abilities in smelling


Mammals like humans lose their ability to smell with age. Researchers have now investigated why this happen. For the analysis, the researchers followed the stem cell development in the brain of mice with so-called confetti reporters.

Disorders of the sense of smell impair the quality of life

A few years ago, researchers from the USA reported on their study, according to which the nose not only contained 10,000 different odors but perceives about a trillion (1,000,000,000,000) odors. However, if the olfactory cells do not work properly, you will lose a lot of quality of life. Disorders of the sense of smell mean a massive restriction in the everyday life of those affected. However, with increasing age, the sense of smell in humans ̵

1; as in other mammals – decreases. Why this is so has been researched by an interdisciplinary research team from the Helmholtz Zentrum München and the Mainz University Medical Center in the journal "Cell Reports".

Stem cell-derived olfactory nerves

In mammals, the formation of nerve cells (neurogenesis) is predominantly restricted to early childhood and occurs in adulthood only in a few regions of the forebrain. [19659008] Such an exception are olfactory nerves, which result from several intermediate stages of stem cells.

"The production of these nerve cells is running out with increasing age," explains the head of the working group at the Institute of Computational Biology (ICB) of Helmholtz Zentrum München. Carsten Marr, in a Communication.

"We wanted to clarify in the current work, how it comes to it and what contribution the stem cells have," said the scientist.


To pursue this question, formed Dr. Marr with mathematician Lisa Bast and stem cell researchers Filippo Calzolari (today at the Institute of Physiological Chemistry of the University Medical Center Mainz) and Prof. Dr. med. Jovica Ninkovic is an interdisciplinary team of experts.

"Our approach to the current work works through so-called confetti reporters in mice: we bring individual stem cells and all their progeny – so-called clones – to glow in a specific color," explains Dr. Calzolari.

In this way, the researchers were able to track the development of individual clones and distinguish them as dots of different colors, giving the procedure its name.

"By comparing young and older mice, we wanted to find out in the next step what contribution single stem cells and intermediate stages contribute to the neurogenesis of the finished olfactory cells, "continued Calzolari.


Fewer cells develop into olfactory cells in old age

However, the systematic evaluation of images is hardly manageable for humans: the available data were extreme heterogeneous and a comparison of young and old brains difficult.

Marr and his team to bear. They are specialists in the quantification of single-cell dynamics, ie the question: which and how many cells of a large association are developing further?

Scientists use artificial intelligence, design mathematical models and program algorithms that evaluate the image data for them

"We compared the confetti measurements with several mathematical models of neurogenesis," explains Lisa Bast.

"In this way, we found that, especially in certain intermediate stages – the so-called transit amplifying progenitors – the In addition, the analysis shows that so-called asymmetric cell division in stem cells as well as their resting phases increased in older mice.

"This means that fewer cells develop into olfactory cells and become inactive in the elderly Stem cell pool remain, causing the product According to Jovica Ninkovic,

the work is the first to allow scientists to quantitatively study the behavior of nerve stem cells in the living mammalian brain using a mathematical model. (Ad)

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Cholesterol-lowering drugs: Statins reduce brown adipose tissue....

Taking cholesterol-lowering drugs can help reduce the risk of heart disease. However, these drugs also increase the risk of certain conditions like diabetes. And as researchers have now found, statins also reduce the beneficial for the health brown adipose tissue.

Nutrition change and medication

About every third German citizen, the cholesterol is too high. An elevated cholesterol level can lead to diseases of the vessels, with possible consequences such as a heart attack or stroke. In order to lower the cholesterol, a diet change is usually recommended. Often also cholesterol-lowering drugs are used. However, medical specialists criticize the fact that such preparations are prescribed too often and in many cases do more harm than good as they can, among other things, cause muscle problems and increase the risk of diabetes. In addition, researchers have now found that reducing cholesterol also reduces the beneficial for the health of brown adipose tissue.

Adults have brown adipose tissue in addition to white

According to experts, humans possess not only white but also brown adipose tissue. The latter helps to convert sugar and fat into heat.

Those with brown adipose tissue can better regulate their body heat in winter and suffer less from obesity and diabetes.

An international team of researchers led by Christian Wolfrum Professor of the Translational Nutritional Biology Unit at the Swiss Federal Institute of Technology in Zurich (ETH Zurich) has now discovered that the drug class of statins reduces the formation of brown adipose tissue.

Statins lower blood cholesterol levels and help reduce heart attack risk prescribed. According to a statement from ETH Zurich, these preparations are among the most widely used medications worldwide.


Statins reduce activity of brown adipose tissue


Wolfrum and his colleagues have been researching brown adipose tissue for years. Scientists explored how the "bad" white fat cells that make up the known fat deposits produce "good" brown fat cells.

In cell culture experiments, they have now discovered that the pathway responsible for producing cholesterol plays a central role in this transformation.

The key molecule that regulates the transformation was identified by the researchers as the metabolite geranylgeranyl pyrophosphate.

As known from previous studies, the cholesterol pathway is also central to the action of statins , Among other things, statins lead to a reduced formation of geranylgeranyl pyrophosphate.

Therefore, the researchers wanted to know whether statins also influence the formation of brown adipose tissue. They are indeed doing that, as the scientists have now shown in studies in mice and humans.

Among other things, the experts evaluated positron emission tomography images of around 8,500 patients at the University Hospital in Zurich. In these pictures, the scientists were able to detect whether the persons possess brown adipose tissue.

In addition, the patients knew whether they had to take statins. The evaluation showed that among those who did not need to take such medication, six percent had brown adipose tissue. Only one percent of those taking statins had such tissue.

In an independent 16-person clinical study at the University Hospitals in Basel and Zurich, researchers were able to show that statins reduce the activity of brown adipose tissue.


Cholesterol-lowering drugs save millions of lives


Although the study reveals a negative effect of statins, the ETH Zurich professor warns against misinterpreting them.  "One must also weigh in the balance that statins are incredibly important for the prevention of cardiovascular diseases. These medicines save many millions of people worldwide and are prescribed for good reasons, "said Wolfrum.

However, there is another negative effect of statins: taken high doses, they increase the risk of developing diabetes in certain people, such as from other studies.

"These two effects – the reduction of brown adipose tissue and the slightly increased risk of diabetes – may be related," says Wolfrum. However, this must first be examined in more detail.

But even if such a connection were to prove true, it would not be a matter of demonizing statins, emphasizes the ETH professor.


Rather, one would have to investigate the mechanisms of action in further research investigate which patients are affected by the negative effects.

It may be possible to continue to recommend statins with personalized medicine approaches in the majority of patients but would suggest alternative therapies to a small group of patients. (Ad)

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Admissibility of pathological amyloid-beta proteins confirmed.....

Alzheimer's disease is a dreaded neurodegenerative disease affecting mainly elderly people, whose prevalence has increased dramatically in recent decades. As early as 2015, researchers from University College London had suggested that the disease could be transmissible via the misfolded amyloid proteins. In laboratory experiments on mice they now confirmed the suspicion.

Alzheimer's disease is considered a non-communicable disease. It threatens no infection in the ordinary contact with stakeholders, emphasize the British scientists. However, a 2015 study has already shown that the pathological amyloid beta proteins may be transmitted from human to human as part of medical treatment. In their current study, researchers at University College London have confirmed this. Their findings have been published in the journal Nature.

Hormone therapy transmission?

"Our previous study found that some individuals who had Creutzfeldt-Jakob disease many years after treatment with pituitary growth hormone also developed Deposits in the brain of an abnormal protein that is characteristic of Alzheimer's disease, "says lead author of the study, Professor John Collinge, from the starting point of the current study. The reason suspected the researchers in the transmission of the misfolded protein structures with the growth hormones. In their current research, they have now shown that the pituitary growth hormone actually contained the corresponding amyloid beta proteins.

Growth Hormone Contamination Detected

"The findings support the hypothesis that amyloid beta has undergone this long-discontinued medical treatment accidentally transmitted to patients, "explain the scientists in a press release. Human growth hormone – made from human tissue prior to 1985 – actually contained Alzheimer's disease amyloid beta protein deposits. In the next step, the research team examined whether the growth hormone protein contaminants also lead to the development of the amyloid deposits typical of Alzheimer's disease.

Mouse Experiments

The researchers injected the contaminated growth hormone into the brain and genetically manipulated mice found that after less than twelve months, "a clear seeding of the amyloid pathology in their brain" already took place. The same was observed in mice injected with tissue from patients with typical Alzheimer's disease. In contrast, mice injected with synthetic growth hormone or normal brain tissue did not show such patterns.


Amyloid beta pathology is transmittable

"We have now presented experimental evidence to support our hypothesis that amyloid beta Pathology can be transferred from contaminated materials to humans, "said Professor Collinge. However, it is not yet clear whether or not Alzheimer's disease can be caused or transmitted to humans through medical or surgical interventions. "It will be important to review the risks of transmitting amyloid pathology in other medical procedures that are still in use today – including brain surgery tools," said the expert.

Contraindications to contact with Alzheimer's disease [19659002] The current study provides new insights into the molecular mechanisms underlying the role of amyloid in Alzheimer's disease, but the researchers explicitly emphasized that there is currently no evidence of Alzheimer's between humans. The study gives no indication that you can get Alzheimer's disease through contact with a sick person. (Fp)

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