Author|Prof.Dr./ Aboelfetoh M. Abdalla
Moringa oleifera has long been used in traditional med-icine. While data collected from human subjects are limited,
several trials demonstrating potential benefits for treating hyperglycemia and dyslipidemia primarily in people with type 2 diabetes have been published.
In a single dose study with six type 2 diabetic subjects, the feeding of 50 g of a M. oleifera leaf powder with a standard meal on a one-time basis decreased blood glucose levels by 21% (William et al., 1993). The authors concluded that the reduced blood glucose response to M. oleifera was not due to alterations in insulin secretion.
Kumari (2010) treated type 2 diabetic subjects with 8 g of powdered M. oleifera leaf in a tablet form per day for 40 days. A total of 46 subjects were involved in the study. At the end of the study, fasting blood glucose and postprandial blood glucose were 28% and 26% lower, respectively, in the treated subjects. Furthermore, total cholesterol, triglycerides, Low density lipoprotein (LDL)-cholesterol, and very low density lipoprotein-cholesterol were 14%, 14%, 29%, and 15% lower rela-tive to the control group.
Nambiar et al. (2010) examined the anti-dyslipidemic effects of M. oleifera in 35 type 2 diabetic subjects. The treated group received 4.6 g of a leaf powder in a tablet form daily for 50 days. Compared with the control group, the treated subjects experienced a 1.6% decrease in total plasma cholesterol and a 6.3% increase in HDL. Comparing this study with the previous studies suggests that higher doses may be more effective.
Ghiridhari et al. (2011) conducted a study in which 60 type 2 diabetic subjects were given two M. oleifera leaf powder tablets per day or placebo for up to 3 months. Unfortunately, the weight of the tablets and therefore the actual dose of the leaf powder were not given. After 3 months, postprandial blood glucose had decreased by 29% relative to the control group, while hemoglobin A1C, an index of glycosylation related to blood glucose levels, decreased by 0.4%.
In another human study, Kushwaha et al. (2012) studied 30 postmenopausal women who were supple-mented daily with 7 g of M. oleifera leaf powder for a period of 3 months. A control group also consisted of
30 postmenopausal women. The data revealed significant increases in serum glutathione peroxidase (18.0%), su-peroxide dismutase (10.4%), and ascorbic acid (44.4%), with decreases in malondialdehyde (16.3%; lipid peroxi-dation), markers of antioxidant properties. In addition, a significant decrease in fasting blood glucose levels (13.5%) as well as an increase in hemoglobin (17.5%) was observed. No adverse effects were reported.
In summary, the previous human studies indicate that
whole leaf powders of M. oleifera given orally exhibit significant anti-hyperglycemic, anti-dyslipidemic, and antioxidant effects in human subjects without produc-tion of adverse effects. None of these studies involved the use of leaf extracts.
As this research has a great importance as we move on research or experiments on animals now move on to the research to humans exhibiting in this file, an entire paper published for the first time in Egypt and the Arab world through us, where our effort is widely used in the framework of search and blogging, translation, and what We got through the Egyptian scientific Society Research for Morinja ,We are pleased that Castle Journal, which is leading an awareness campaign in support of the tree Moringa in Egypt and support the efforts of the scientific research that on the track we could produce medicines and food, and contribute to the production of the national economy by providing an effective treatment for many of the humans and animal . we hope that this campaign and what we offer from the research effort and the results confirmed the validity of what we do to be in favor of the nation and all the peoples.
Prof.Dr./ Aboelfetoh M. Abdalla
Head of The Egyptian Scientific Association for Moringa
National Research Centre (NRC), Dokki, Cairo, Egypt